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Enter fasting glucose and insulin measured at the same time. We calculate HOMA-IR with the original Matthews equation — a useful research marker of insulin sensitivity, but not a stand-alone diagnosis.
Research and laboratory practice often use reference points around 2–2.5, but this is not a universal normal cut-off. The number alone neither confirms nor excludes insulin resistance.
The calculation only makes sense for simultaneous fasting samples, before food or caloric drinks. It is particularly limited with marked hyperglycaemia, insulin treatment or impaired beta-cell function.
Please note: HOMA-IR has no universal diagnostic cut-off: references depend on population and insulin assay. Compare the result with your laboratory's range and interpret it alongside glucose, HbA1c and clinical context.
Source: Matthews et al., Diabetologia, 1985. HOMA-IR = fasting glucose (mmol/L) × fasting insulin (µIU/mL) / 22.5. With glucose in mg/dL, the equivalent denominator is 405.
Multiply fasting glucose in mmol/L by fasting insulin in µIU/mL and divide by 22.5. If glucose is in mg/dL, divide the product by 405.
A higher result suggests greater insulin resistance within a studied population, but there is no single diagnostic cut-off. References around 2–2.5 are common but do not replace your laboratory range or clinical assessment.
Simultaneous fasting samples are required. The result depends on the insulin assay and is especially limited with marked hyperglycaemia, insulin treatment or impaired beta-cell function.
Take the short health-factor map and see how this connects to your own lifestyle.